Prusias was born to
Prusias I and
Apama III in 220 BC. His father died in 189 BC, at which point he became the king of Bithynia. Prusias II joined with the king of
Pergamon,
Eumenes II in a war against King
Pharnaces I of Pontus (181–179 BC). He later invaded the territories of
Pergamon (156–154 BC), only to be defeated, with Pergamon insisting on heavy reparations, including 500 talents and "twenty decked ships". Prusias II married his maternal cousin
Apame IV, a sister of
Perseus of Macedon and a princess from the
Antigonid dynasty, by whom he had a son, Nicomedes II, and a daughter, Apama, who would marry Dyegilos, son of
Cotys IV, King of
Thrace, and his wife, Semestra. Prusias II was honoured by the
Aetolian League with a
stele at Delphi on account of his behavior and benefactions towards them. He sent Nicomedes to Rome to ask its help in reducing the amount of these reparations, and directed the co-ambassador, Menas, to kill Nicomedes if the mission was unsuccessful. Despite the failure of the mission, Nicomedes persuaded Menas to betray Prusias, and Nicomedes declared himself king. Prusias had to renounce the kingship in favour of his son and was himself murdered in 149 BC. ==References==