Mimosa tenuiflora is an
entheogen used by the Jurema Cult (
O Culto da Jurema) in northeastern Brazil. Dried Mexican
Mimosa tenuiflora root bark has been shown to have a
dimethyltryptamine (DMT) content of about 1-1.7%. The parts of the tree are traditionally used in northeastern Brazil in a
psychoactive decoction also called
Jurema or Yurema. Analogously, the traditional Western Amazonian sacrament
Ayahuasca is brewed from indigenous
ayahuasca vines. However, to date no
β-carbolines such as
harmala alkaloids have been detected in
Mimosa tenuiflora decoctions, yet the Jurema is used in combination with several plants. This presents challenges to the pharmacological understanding of how DMT from the plant is rendered orally active as an entheogen, because the psychoactivity of ingested DMT requires the presence of a
monoamine oxidase inhibitor (MAOI), such as a β-carboline. If an MAOI is neither present in the plant nor added to the mixture, the
enzyme monoamine oxidase (MAO) will metabolize DMT in the human gut, preventing the active molecule from entering the blood and brain. The plant is also used in
clandestine manufacture of crystalline DMT. In this form, it is psychoactive by itself when vaporized and inhaled. The isolation of the chemical compound
yuremamine from
Mimosa tenuiflora as reported in 2005 represents a new class of phytoindoles, which may explain an apparent oral activity of DMT in Jurema. ==Cultivation==