Duplass has written, directed, and produced several feature films with his brother Jay Duplass. In 2005, he wrote and produced
The Puffy Chair with his brother, in addition to portraying one of the main characters. The two brothers later wrote, directed, and produced the films
Baghead (2008) and
Cyrus (2010) together and have a unique style which consists of a great deal of ad-libbing off of the original script, shooting a number of takes, and editing scenes down 15 to 20 times. Their films
Jeff, Who Lives at Home and
The Do-Deca-Pentathlon were released in 2012. In 2014, Duplass co-wrote, produced and starred in the
horror film Creep alongside
Patrick Brice, appearing in the film as Josef. In May 2016, it was announced that there would be a sequel to
Creep.
Creep 2 was released in October 2017 which Duplass again co-wrote and starred in. In 2009, Duplass starred in the FX comedy television series
The League, with his wife, Katie Aselton. In 2015, the HBO series
Togetherness debuted, which was created by and stars Duplass. That same year, Duplass co-starred with
Evan Peters and
Olivia Wilde in David Gelb's thriller film
The Lazarus Effect. In 2015, both Mark and Jay Duplass via their Duplass Brothers Television banner signed a two-year overall deal with HBO. In 2018, he appeared in
Tully and
Duck Butter, and released his debut book
Like Brothers alongside
Jay Duplass. He also starred as real estate developer Tom Wyatt in Season 2 of the
Amazon Video series
Goliath. In 2019, Duplass starred in the
Netflix comedy film,
Paddleton, in which he was also a co-writer and executive producer. Duplass was named the 2022-2023 Frank Sinatra
Artist-in-Residence at
Santa Clara University on July 22, 2022. ==Other ventures==