This gene encodes a single-pass type I membrane glycoprotein with two
Ig-like C2-type domains and an
Ig-like V-type domain. This protein is one of the plasma membrane components of
adherens junctions. It also serves as an entry for certain mutant strains of
herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in this gene have been associated with differences in the severity of multiple sclerosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. ==See also==