Pyxine cocoes grows on bark and rocks. The lichen has been reported from Asia (Japan and the Philippines), East Africa, North America, Central America, and South America, Hawaii, and Australia. In Australia, it is present only in coastal locations that are seasonally humid, and both wet and warm. In this continent, it is common on tree trunks growing on coral
cays; these trunks are often used as bird perches, which accumulate bird droppings. The lichenologist
Roderick W. Rogers suggests that the lichen could be
nitrophilic, which would explain this growth habitat, as well as its tendency to prefer habitats that are at least partially
urbanized. In North America, it distribution extends as far north to
Florida in the United States. The African species
Pyxine katendei is somewhat similar in appearance to
Pyxine cocoes, but it has only laminal (not marginal) soralia. ==Biomonitoring studies==