Theliderma intermedia, the Cumberland monkeyface pearly mussel or Cumberland monkeyface, is a species of freshwater mussel in the family Unionidae, the river mussels. This aquatic bivalve mollusk is native to Tennessee and Virginia in the United States. Historically widespread in the upper Tennessee River system, it populations have been reduced by habitat destruction and pollution. It now only occurs in two tributaries: the Duck and Powell Rivers. It is a federally listed endangered species.