The label's origins trace back to the friendship between Walter Roblero and Rodrigo Santis, who met at the
Instituto Nacional in Santiago, and would later form the band Congelador around 1996 as a trio with Rodrigo's brother, Jorge Santis. Looking for options to release their music, the group received proposals from certain labels to help produce their debut album, but they preferred full creative freedom and control, rejecting the limited offers. Around 2002–2004 the structure changed following the departure of Walter Roblero, who pursued other ventures including human rights work. Rodrigo Madrid, civil engineer and business consultant, joined the label structure around 2003 after investing in Mostro's album
HR=01, helping with its financing and regularization of its legal status. In 2007, Quemasucabeza embarked on the
Neutral 2007 Tour, its first major international outing with a full contingent, where various of its artists performed in Mexico and Argentina. This year they also founded the agency Armónica to produce and organize concerts, which served as an extra source of income for both the label and its artists. In 2018, the label celebrated its twentieth anniversary with a special edition of their Festival Neutral in Mexico, which featured several key artists for the label, including Familea Miranda, Mostro, Congelador, Fredi Michel,
Ana Tijoux,
Pedropiedra, and Gepe. == Artists ==