Mitchell was selected by the
Philadelphia Eagles in the first round (22nd overall) of the
2024 NFL draft. His jersey number was initially assigned to No. 30, but switched to No. 27 ahead of the regular season following the departure of
Zech McPhearson.
2024 season During his rookie year, Mitchell was known for his consistent coverage skills against receivers such as
Drake London,
Ja'Marr Chase, and
Mike Evans. Most notably, during the week 11
Thursday Night Football matchup between the
Washington Commanders, Mitchell held wide receiver
Terry McLaurin to 0 targets, 0 receptions, and 0 yards. Due to his efficiency against guarding
wide receivers, Mitchell was nicknamed "
Quinyonamo Bay"; a reference to the
United States military prison Guantanamo Bay, and his colloquial status as a "lockdown corner". He was named to the PFWA All-Rookie Team for his 2024 season. Mitchell would record his first career interception in the 22–10 win over the Green Bay Packers in the wild-card round of the 2024 NFL playoffs. In the
2024 NFC Championship game, Mitchell intercepted quarterback
Jayden Daniels enroute to a blowout win 55–23. Mitchell became a
Super Bowl champion following the Eagles 40–22 win over the
Chiefs in
Super Bowl LIX. Mitchell finished in second-place for the AP NFL
Defensive Rookie of the Year award.
2025 season In Week 4, Mitchell recorded five pass breakups and five tackles while only allowing two catches for six yards during a 31–25 victory over the Tampa Bay Buccaneers, earning NFC Defensive Player of the Week honors. Mitchell finished the season 1st among NFL cornerbacks in catch rate allowed (41.6%), 3rd in forced incompletions (12), and 1st in touchdowns allowed (0). Mitchell’s performance in 2025 earned him First-team All-Pro, cementing his status among the NFL’s elite cornerbacks. Mitchell recorded 2 interceptions in the 23–19 loss to the
San Francisco 49ers in the
Wild Card Round. ==NFL career statistics==