Quirino Highway starts from
Epifanio de los Santos Avenue, near the
Balintawak Cloverleaf in
Quezon City. It then runs shortly in parallel to
North Luzon Expressway (NLEX) carrying one-way northbound traffic and turns northeast towards the northwestern part of
Quezon City. It then meets the Old Novaliches and New Novaliches Flyovers, connecting it to NLEX. The highway turns right at Novaliches Proper, approaching the area of Fairview, where it becomes a one-way westbound highway between Belfast Street to
Regalado Highway, adjacent to
Robinsons Novaliches and
SM City Fairview. Its length from there to Araneta Avenue in Pangarap Village,
Caloocan is followed by the under-construction elevated
MRT Line 7 line. The road ends its N127 designation as it enters north Caloocan. Crossing the Marilao River, it then enters the province of
Bulacan at
San Jose del Monte, straddling along the mountainous terrain, and ends at the roundabout with Villarama Road and Ipo Road in Bigte,
Norzagaray. Past the roundabout, it is continued by Ipo Road that leads to
Ipo Dam. The highway is also the alternate route for motorists en route to
Baliwag and up to
Cagayan Valley via Cagayan Valley Road. ==Intersections==