Its south-western terminus is a junction with the
R513 road just north-east of
Pretoria,
Gauteng (east of
Montana Park). It heads north-east for 48 kilometres, through
Kameeldrift, bypassing the
Roodeplaat Dam and
Roodeplaat Nature Reserve, to enter
Mpumalanga at the town of Moloto and proceed to the town of
KwaMhlanga, where it meets the
R568 road. It continues east-north-east for 26 kilometres to the town of
Kwaggafontein. Just before Kwaggafontein, it meets the northern terminus of the
R544 road. From Kwaggafontein, the R573 continues north-east to bypass
Mathys Zyn Loop and
Boekenhouthoek before crossing into
Limpopo at the town of
Witfontein. Soon after, the R573 meets the R568 again and temporarily crosses back into Mpumalanga, entering the town of
Siyabuswa. The distance from Kwaggafontein to Siyabuswa is 24 kilometres. Just after Siyabuswa, the R573 crosses back into Limpopo and continues north-east for 30 kilometres to end at a junction with the
R33 and
N11 national route in
Marble Hall, just south of the town centre. ==State of Road==