In the May 2010
Tower Hamlets Council election, Khan won a seat in
Shadwell for the
Labour Party. In October 2010, she was suspended along with nine other councillors from the Labour Party for supporting the newly elected
independent Mayor of Tower Hamlets,
Lutfur Rahman. In
May 2014, she was re-elected in the Shadwell ward as a candidate for
Tower Hamlets First, a party set up by Rahman. She was a member of Tower Hamlets First until it was disbanded in April 2015 following electoral corruption by Rahman. From October 2010 to April 2015, Khan was also the Cabinet Member of Housing. In April 2015, Khan along with the remaining 17 Tower Hamlets First councillors was described by Commissioner
Richard Mawrey QC, acting as a judge in an
election court investigating Lutfur Rahman's election, as being elected to Tower Hamlets Council "with the benefit of the corrupt and illegal practices", although Khan was not implicated in any claims of electoral fraud. and all the former Tower Hamlets First councillors. In May 2015, she stood as an
independent candidate and came second to Labour candidate
John Biggs. Khan was subsequently re-elected as a councillor as a member of the
Tower Hamlets Independent Group (THIG). In November 2016, she defected from THIG to form the
People's Alliance of Tower Hamlets (PATH), In May 2018, Khan stood in the
elections for the directly elected Mayor of Tower Hamlets. She came second and was re-elected as a councillor,
PATH's only win and the only former Tower Hamlets First seat not taken by Labour. Khan disbanded PATH in August 2018 with her and her fellow members joining the
Liberal Democrats, making her the only Liberal Democrat councillor on Tower Hamlets Council. In the
2019 European Elections she was a candidate for the Liberal Democrats in the London region. In September 2019, she was announced as the Liberal Democrat candidate for
Kensington for the
2019 United Kingdom general election. She was appointed to be the Communities Special Advisor to the Liberal Democrat Leader in the House of Lords, Lord Newby.
Sam Gyimah MP, elected as a
Conservative but who had defected to the LibDems, became the candidate instead; he came third in the election. She stood in the 2022 Tower Hamlets Mayoral contest for the Liberal Democrats and for reelection to her Shadwell seat. She lost both. However, her mayoral candidacy helped the Liberal Democrats supplant the Conservatives for the first time in the borough's mayoral vote. ==Awards and nominations==