Plans for the Hospital began in 1951 when the Board of the San Diego
Society for Crippled Children initiated construction plans for a new children's hospital. In 1953, Children's Hospital Auxiliary was formed and, later that year, groundbreaking took place. On August 19, 1954, the Children's Hospital of San Diego opened to receive its first 12 patients. Since then, nearly 2 million sick and injured children have been treated at the hospital. In 1985,
Dr. David Chadwick founded the Center for Child Protection at the Children's Hospital of San Diego where he was director until his retirement in 1997. In 2001, the Children's Hospital of San Diego formed a partnership with the
University of California-San Diego to unify pediatric patient care, research, education, and community service programs. In 2006, Ernest and Evelyn Rady made a donation of $60 million to Children's Hospital of San Diego, and the hospital was renamed Rady Children's Hospital-San Diego in their honor. The Rady family followed up with a gift of $120 million in 2014 to support the hospital's Institute for Genomic Medicine, and a pledge of $200 million in 2019. Harry Rady is a member of the Rady Children's Hospital Board of Trustees and is on the Dean's advisory board at the
Rady School of Management at UCSD. On October 10, 2010, Rady Children's opened the Acute Care Pavilion, a LEED-Certified (green) building that is home to the new Peckham Center for Cancer and Blood Disorders, the Warren Family Surgical Center, and a
Neonatal Intensive Care Unit that cares for the community's tiniest and most fragile babies.
Partnership with Children's Specialized Hospital In 2019,
Children's Specialized Hospital,
New Jersey announced a partnership with Rady Children's Hospital,
San Diego CA. The partnership helps to establish the first inpatient children's chronic pain program in Southern California. The program helps to provide pain relief for children and adolescents without using opioids. The new unit is branded with CSH's branding and the unit follows CSH policies on pediatric chronic rehabilitation and pain relief in children and teens up to the age of 21.
Merger with Children's Health Orange County and CHOC Children's In November 2023, Rady Children’s Hospital and
Children's Hospital of Orange County (CHOC) announced their intent to merge, forming one of the largest pediatric healthcare networks in California. According to representatives from both organizations, this partnership aims to enhance pediatric healthcare delivery by integrating specialized services, research initiatives, and advanced technologies under one unified system. The merger is expected to streamline clinical operations, expand community outreach, and improve access to comprehensive pediatric care for families across Southern California. In January 2025, it was announced that the merger between the two institutions had been completed. ==Employees==