Palladino started his senior career at
Sporting Benevento, before joining the youth ranks of
Juventus in 2002, where he achieved the
Torneo di Viareggio in
2003 and
2004. On 27 August 2005, he scored his first goal for the latter on his
Serie A debut, securing a 2–1 victory over
Lecce. He then returned to Juventus senior team in 2006–07, as the club were relegated to Serie B. He started and scored his first goal in a 1–1 away draw against
AlbinoLeffe on 18 November 2006. On 19 March 2007, he netted his first career hat-trick in a 5–1 victory over
Triestina. He eventually won the Serie B title
that season with his club, securing an immediate promotion to the top-tier division. On 3 July 2008, Palladino was signed by
Genoa in
co-ownership deal, priced €5 million (for 50% rights), joined along with defender
Domenico Criscito on loan. On 3 January 2011, Genoa's half share in Palladino was transferred to
Parma in a move which saw Parma's half share in
Alberto Paloschi go the other way and the exchange of the full registration of
Francesco Modesto and
Luca Antonelli. Genoa also paid a sum of €5.85M cash. In June 2011, Juventus gave up the remaining 50% registration rights to Parma for free. In July 2013, he extended his contract to 30 June 2016. On 10 November 2015, he was signed by
Crotone. He renewed his contract in July 2016. On 31 January 2017, Palladino was re-signed by
Genoa. On 15 January 2018, he signed for Serie B club
Spezia. On 31 March 2019,
Monza announced the signing of Palladino. ==International career==