George, Lizzie, and Ralph, who are returned to normal size following the events of
World Tour, have been captured and confined for the world to see. George is held captive in
New York City, Lizzie is imprisoned in
Tokyo, and Ralph the
Wolf is stored in
London (references to
King Kong,
Godzilla, and
Werewolf of London, or possibly
An American Werewolf in London). However, Scumlabs, who has just rebuilt their facilities in
Salt Lake City, causes another accident that results in three new monsters: Boris (a
rhinoceros monster), Curtis (a
mouse monster), and Ruby (a
lobster monster). Players choose one of the three original monsters to rescue. The player then uses the characters in the part of the world where the rescuee is held. They work as a collective to break buildings, eat people, and destroy cars and this creates competition among players. When a player frees George, Lizzie, or Ralph, then they become playable characters. Once all the monsters are rescued,
aliens begin to invade Earth in an attempt to conquer it, leaving the monsters the only ones who can save the planet that they just helped partially destroy. After fending off the invasion on Earth, the monsters rescue Myukus (a green
cyclops-like alien) from Area 51, who joins them before chasing the aliens through space, destroying the aliens' bases throughout the
Solar System and eventually rampaging through their home-world and destroying their capital. A news channel covers all the destruction caused by the monsters. At the end of the game, it is revealed that the aliens have a news program of their own, but the alien anchorman who runs the program is eaten by Myukus. ==Gameplay==