Early medical texts, especially the
Carakasaṃhitā and
Suśrutasaṃhitā, are often claimed to contain early references to
rasaśāstra. Where these texts use the word
rasa, later commentators interpret
rasa as mercury, despite the word having various other meanings. The earliest mentions of mercury are to the unprocessed substance and it is not until the 9th century
Kalyāṇakāraka that we find recipes for purifying and calcination. The 13th century
Śārṅgadharasaṃhitā also contains elaborate descriptions of the processing and uses of mercury. An important feature is the use of metals, including several that are
toxic. In addition to mercury,
gold,
silver,
iron,
copper,
tin,
lead,
zinc and
bell metal are used. In addition to these metals,
salts and other substances such as
coral,
seashells, and
feathers are also used. The usual means used to administer these substances is by preparations called
bhasma,
Sanskrit for "ash".
Calcination, which is described in the literature of the art as
śodhana, "purification", is the process used to prepare these
bhasma for administration.
Sublimation and the preparation of a mercury
sulfide are also in use in the preparation of its
materia medica. A variety of methods are used to achieve this. One involves the heating of thin sheets of metal and then immersing them in oil (
taila), extract (
takra), cow urine (
gomutra) and other substances. Others are calcined in
crucibles heated with fires of cow dung (
puttam). Ayurvedic practitioners believe that this process of purification removes undesirable qualities and enhances their therapeutic power. ==Toxicity==