Clough made contributions in the field of earthquake engineering, in particular with the development and application of a mathematical method,
finite element analysis, which has applications in numerical modeling of the physical world. Dr. Clough extended the method to enable
dynamic analysis of complex structures and co-authored, with Joseph Penzien, a text on
structural dynamics. As of 2025, the second edition (revised) of this text is still in print and widely used. A series of papers that appeared in the 1960s and 1970s presented new and accurate methods utilizing the finite element concept for earthquake analysis of earth dams and concrete dams. During the 1970s and 1980s he directed his research toward experiments on concrete, steel, and masonry buildings and liquid-storage tanks using the UC Berkeley EERC shaking table. Clough and Joe Penzien with support from
Jack Bouwkamp developed the Earthquake Engineering Research Center (EERC) at UC Berkeley, a hub for analytical engineering research, information resources, and public service programs. The proposal was submitted in 1967 and EERC began operations in 1968. ==Awards and honors==