Dwek read chemistry (1960–64) at the University of Manchester. He completed his DPhil in physical chemistry at Oxford in 1966. Following this, he became a research lecturer at
Christ Church, Oxford, where he taught physical and inorganic chemistry. In 1969, he was invited to join the Biochemistry Department, working with other members of the Oxford Enzyme Group. In 1974, he was elected Royal Society Locke Research fellow, working on antibodies. This led to his appointment as university lecturer in biochemistry with a fellowship, by special election, at Exeter College in 1976. At the same time, he was also appointed a lecturer in biochemistry at
Trinity College to help build up the subject there. Dwek's research on antibodies led directly to defining the function of the attached
oligosaccharides and from which the field of glycobiology emerged – a word coined by Dwek which entered the
Oxford English Dictionary in 1992. In 1988, Dwek was made Professor of Glycobiology. In 1985, Dwek secured the first industrial grant to Oxford University in its 950-year history, from
Monsanto Company USA, which was developing a pharmaceutical arm. The grant was to develop the technology for sequencing oligosaccharides. Over 13 years the value of the grant was almost $100M. In 1991, Dwek became Director of the Glycobiology Institute which he founded and which was built with funds from Monsanto/
Searle. Also in 1988, Dwek was the founding scientist and non-executive director of Oxford GlycoSciences Plc (formerly Oxford GlycoSystems), which was established to commercialise technologies arising from his research at the Glycobiology Institute. In 1995, the company was mentioned as part of the
Queen's Anniversary Prize to the University of Oxford. In 1998, it was publicly quoted on the
London Stock Exchange. In 2002 in collaboration with Glycobiology Institute, Oxford GlycoSciences had a drug for
Gaucher disease approved worldwide. In 1998, Dwek was also the founding scientist and chairman of the Scientific Board and Director of Synergy, which was established in the United States to develop antiviral agents for the treatment of chronic
Hepatitis B and C infections. This work was taken over by
United Therapeutics, USA, and Dwek became a director of this company in 2002 and continues this appointment. The company sponsored the antiviral laboratory at the Glycobiology Institute from 2002 to 2017 and continues its sponsorship of the Annual Unither Barry Blumberg Virology Lecture at Oxford University (2004-2027). Dwek is the author of
Nuclear Magnetic Resonance (NMR) in biochemistry – application to enzyme systems (OUP, 1973),
Principles and Problems in Physical Chemistry for Biochemists, with N C Price (OUP, 1974) and
Biology Spectroscopy with
I D Campbell (Benjamin Cummings, 1984). He has published over 600 peer reviewed articles and about 100 patents. ==Awards and recognition==