The protein encoded by this gene is part of a complex termed
negative elongation factor (NELF) which represses
RNA polymerase II transcript elongation. This protein bears similarity to nuclear RNA-binding proteins; however, it has not been demonstrated that this protein binds RNA. The protein contains a tract of alternating basic and acidic residues, largely arginine (R) and aspartic acid (D). The gene localizes to the major histocompatibility complex (
MHC class III) region on chromosome 6. == Interactions ==