•
Dominic Janes as Jimmy Roberts, a middle school student who has Milt Appleday's preserved brain transplanted into his head, enabling him to experience and interact with visions of cartoon characters. •
Matt Knudsen as Sonny Appleday, Milt Appleday's scheming son, who is determined to claim his father's brain for himself. •
Bil Dwyer as Ken Roberts, Jimmy and Yancy's father. •
Eunice Cho as Robin Yoshida, Craig's sister and Jimmy's crush. • Micah Karns as Craig Yoshida, Robin's brother and Jimmy's so-called best friend. • Rhea Lando as Yancy Roberts, Jimmy's adopted older sister from an alien planet. • Rachel Quaintance as Louisa Roberts, Jimmy and Yancy's mother. •
Tom Kenny as Appleday Board Member. •
Fred Willard as Milt Appleday, a deceased animator who founded Appleday Pictures and created the characters Jimmy sees. He is loosely based on animator
Walt Disney. • Willard also voices a robot made in Milt's likeness •
Stephanie Courtney as Donna.
Voice cast •
Paul Reubens as Golly Gopher, an energetic but rude and selfish
gopher and Milt Appleday's most famous character. He is loosely based on
Disney character and mascot
Mickey Mouse •
Ellen Greene as Dolly Gopher, Golly's female counterpart and love interest. She is loosely based on Disney character
Minnie Mouse. •
Tom Kenny as Tux, a
penguin who enjoys performing stand-up comedy despite his inability to tell jokes. He is loosely based on Disney character
Donald Duck. •
Brian Posehn as Crocco, a bumbling but outgoing
alligator. He is loosely based on Disney character
Goofy. Two nonverbal cartoon characters, Prickles and Pickles (a
porcupine and a
pickle, respectively), also appear. They are loosely based on
Tom Cat and
Jerry Mouse, stars of the
Tom and Jerry animated franchise. ==Production==