The team was founded in 2000 as
Limed Pokrovske and until 2011 played in Odesa. Since 2005 the club was known as
Real-Pharm. In 2010 the club was passed onto
Mykola Lykhovydov who became the club's president and playing manager. Until 2011 the club participated in football competitions of
Odesa Oblast. In March 2011 Real Pharm was registered as a professional club and lost the hyphen in its name. It also joined competitions of the national amateur league, the early stages of the 2011 season. "Real Pharm" debut in the Ukrainian Second League in the 2011–12 season. In 2013, the club moved their operations from
Yuzhne to
Ovidiopol and prior to the
2013–14 Ukrainian Second League season renamed the team to
Real Pharma Ovidiopol. The club moved their operations to
Odesa prior to the start of the
2015–16 season.
Home stadiums • 2011–2013
Spartak Stadium,
Odesa • 2013–2015 Dukov Dnister Stadium,
Ovidiopol • 2015–2016 Ivan Stadium,
Odesa • 2016– present
Spartak Stadium,
Odesa Emblems File:Real Pharm.png|Emblem 2011–2013 File:Real Farma.gif|Emblem 2013–15Based in Ovidiopol File:Real Pharma Odesa 2015.png|Emblem 2015–17 ==Players==