The school is located here. In 1990, a group of Duchesne families founded The Regis School with the goal of being accepted into the
Network of Sacred Heart Schools. The school was scheduled to open in August 1991. In August, 1991, the school opened with 38 students in facilities leased from Holy Cross Lutheran Church. Since these temporary facilities were inadequate, a search was started for a more permanent solution. The Milestones and Administration building was purchased and renovated, and classes began there in August 1992. The school was searching for a permanent site within of Duchesne.
Ninfa Laurenzo, the founder of the
Ninfa's restaurant chain and a grandmother of a student at Regis, was honored at the annual "The Regis Merci" celebration on Wednesday April 13, 1994. The celebration honors individuals who were instrumental to the school's operations. Houston Mayor
Bob Lanier declared that day "Ninfa Laurenzo Day" and presented this proclamation to her at the celebration. In 1995, The Regis School earned
accreditation from the Texas Catholic Conference Educational Department. In April of the same year, The Network of Sacred Heart Schools accepted The Regis School as a provisional member. Full membership was granted in 1998. In late 2010, construction began for a new student center with the demolition of the former pavilion. On January 30, 2012, the school held its first ever career day, where students had the opportunity to hear about a variety of jobs from professional workers.{{ cite web The school held its first large event in the new Student Life Center in a liturgy celebrating Grandparent's Day on October 19, 2012.{{ cite web Regis officially opened the Student Life Center for daily use on November 6, 2012, with its liturgy for the dedication of the new building.{{ cite web
Accreditation Regis was the first school voted into membership in the National Network of Sacred Heart Schools in 1998. Through its reflective process concerning how its community lives the Goals and Criteria, Regis received its SHCOG renewal site visit in March 2009. Regis is also accredited by the Texas Catholic Conference Educational Department, under the auspices of the
Texas Education Agency. The
Independent Schools Association of the Southwest invited Regis to membership as its 86th accredited school in June 2010. ==Campus==