During
World War I, Reiter worked first as a German military physician on the
Western Front in
France. While there, he cared for several soldiers suffering from
Weil's disease, and made his first notable discovery that one of the causative bacteria were
Leptospira icterohaemorrhagica, which had eluded culture methods and identification by other scientists ever since that disease had been recognized in 1886. Later, after being transferred to the
Balkans, where he served in the 1st Hungarian Army, he reported a German lieutenant with non-gonococcal
urethritis,
arthritis, and
uveitis that developed two days after a diarrheal illness and had a protracted course with relapses over several months. The combination of two of the elements, urethritis and arthritis, had been recognized in the 16th century, and the triad had first been reported by
Sir Benjamin Collins Brodie, an English surgeon who lived from 1783 to 1862. Separately from Reiter, the triad was also reported in 1916 by Fiessinger and Leroy. Reiter thought he saw a
spirochete which he called
Treponema forans, related to but distinct from
Treponema pallidum, the causative agent of
syphilis, and erroneously thought it was the cause, calling the disease
Spirochaetosis Arthritica. The error probably was influenced by his previous discovery of
Leptospira icterohaemorrhagica, and by his work on
Treponema pallidum that later enabled others to develop the "Reiter Complement Fixation Test" for syphilis. Nevertheless, the eponym Reiter's syndrome was used for the disease he described, and the syndrome became widely known by that name. == 1918–1939 ==