Reporting bias

Research can only contribute to knowledge if it is communicated from investigators to the community. The generally accepted primary means of communication is "full" publication of the study methods and results in an article published in a scientific journal. Sometimes, investigators choose to present their findings at a scientific meeting as well, either through an oral or poster presentation. These presentations are included as part of the scientific record as brief "abstracts" which may or may not be recorded in publicly accessible documents typically found in libraries or the World Wide Web. Sometimes, investigators fail to publish the results of entire studies. The Declaration of Helsinki and other consensus documents have outlined the ethical obligation to make results from clinical research publicly available. Reporting bias occurs when the dissemination of research findings is influenced by the nature and direction of the results, for instance in systematic reviews. Positive results is a commonly used term to describe a study finding that one intervention is better than another. Various attempts have been made to overcome the effects of the reporting biases, including statistical adjustments to the results of published studies. None of these approaches has proved satisfactory, however, and there is increasing acceptance that reporting biases must be tackled by establishing registers of controlled trials and by promoting good publication practice. Until these problems have been addressed, estimates of the effects of treatments based on published evidence may be biased. ==Case study==

Litigation brought upon by consumers and health insurers against Pfizer for the fraudulent sales practices in marketing of the drug gabapentin in 2004 revealed a comprehensive publication strategy that employed elements of reporting bias. Spin was used to put emphasis on favorable findings that favored gabapentin, and also to explain away unfavorable findings towards the drug. In this case, favorable secondary outcomes became the focus over the original primary outcome, which was unfavorable. Other changes found in outcome reporting include the introduction of a new primary outcome, failure to distinguish between primary and secondary outcomes, and failure to report one or more protocol-defined primary outcomes. The decision to publish certain findings in certain journals is another strategy. == Types of reporting bias ==

Publication bias The publication or nonpublication of research findings, depend on the nature and direction of the results. Although medical writers have acknowledged the problem of reporting biases for over a century, it was not until the second half of the 20th century that researchers began to investigate the sources and size of the problem of reporting biases. Over the past two decades, evidence has accumulated that failure to publish research studies, including clinical trials testing intervention effectiveness, is pervasive. only a small proportion of studies are not published because of rejection by journals. Some reviews have reported that only half or all trials are published. The most direct evidence of publication bias in the medical field comes from follow-up studies of research projects identified at the time of funding or ethics approval. These studies have shown that "positive findings" is the principal factor associated with subsequent publication: researchers say that the reason they do not write up and submit reports of their research for publication is usually because they are "not interested" in the results (editorial rejection by journals is a rare cause of failure to publish). Even those investigators who have initially published their results as conference abstracts are less likely to publish their findings in full unless the results are "significant". This is a problem because data presented in abstracts are frequently preliminary or interim results and thus may not be reliable representations of what was found once all data were collected and analyzed. Controlled trials that are eventually reported in full are published more rapidly if their results are positive. Time lag bias The rapid or delayed publication of research findings, depending on the nature and direction of the results. In a systematic review of the literature, Hopewell and her colleagues found that overall, trials with "positive results" (statistically significant in favor of the experimental arm) were published about a year sooner than trials with "null or negative results" (not statistically significant or statistically significant in favor of the control arm). Many duplicates are published in journal supplements, potentially difficult to access literature. Positive results appear to be published more often in duplicate, which can lead to overestimates of a treatment effect. Location bias The publication of research findings in journals with different ease of access or levels of indexing in standard databases, depending on the nature and direction of results. There is also evidence that, compared to negative or null results, statistically significant results are on average published in journals with greater impact factors, and that publication in the mainstream (non grey) literature is associated with an overall greater treatment effect compared to the grey literature. Citation bias The citation or non-citation of research findings, depending on the nature and direction of the results. Authors tend to cite positive results over negative or null results, and this has been established over a broad cross section of topics. Differential citation may lead to a perception in the community that an intervention is effective when it is not, and it may lead to over-representation of positive findings in systematic reviews if those left uncited are difficult to locate. Selective pooling of results in a meta-analysis is a form of citation bias that is particularly insidious in its potential to influence knowledge. To minimize bias, pooling of results from similar but separate studies requires an exhaustive search for all relevant studies. That is, a meta-analysis (or pooling of data from multiple studies) must always have emerged from a systematic review (not a selective review of the literature), even though a systematic review does not always have an associated meta-analysis. Language bias The publication of research findings in a particular language, depending on the nature and direction of the results. There is longstanding question about whether there is a language bias such that investigators choose to publish their negative findings in non-English language journals and reserve their positive findings for English language journals. Some research has shown that language restrictions in systematic reviews can change the results of the review and in other cases, authors have not found that such a bias exists. Knowledge reporting bias The frequency with which people write about actions, outcomes, or properties is not a reflection of real-world frequencies or the degree to which a property is characteristic of a class of individuals. People write about only some parts of the world around them; much of the information is left unsaid. Outcome reporting bias Bias –also known as spin- in research reporting interventional medical studies could arise from, misleading reporting, misleading interpretation and inadequate extrapolation of the results or conclusions. Research reporting bias can take various forms. Misleading reporting could be attributed to failure to report adverse effects of a certain medical or surgical intervention, selective reporting of results, or inappropriate use of language in the conclusions as overstated conclusions or undue generalizations that are not supported by study's results. A study may be published in full, but pre-specified outcomes omitted or misrepresented. Efficacy outcomes that are statistically significant have a higher chance of being fully published compared to those that are not statistically significant. Contrastingly, a study found low prevalence of bias in the conclusions of non-randomized control trials published in high-ranking orthopedic publications. Control for bias in research reporting can increase trust in the published medical literature and better inform evidence-based clinical practice. Selective reporting of suspected or confirmed adverse treatment effects is an area for particular concern because of the potential for patient harm. In a study of adverse drug events submitted to Scandinavian drug licensing authorities, reports for published studies were less likely than unpublished studies to record adverse events (for example, 56 vs 77% respectively for Finnish trials involving psychotropic drugs). Recent attention in the lay and scientific media on failure to accurately report adverse events for drugs (e.g., selective serotonin uptake inhibitors, rosiglitazone, rofecoxib) has resulted in additional publications, too numerous to review, indicating substantial selective outcome reporting (mainly suppression) of known or suspected adverse events. == See also ==