"Rescue Me" was written and produced by lead vocalist
Jared Leto and music producer KillaGraham. It was engineered by Chris Galland and mixed by
Manny Marroquin with the assistance of Scott Desmarais and Robin Florent. The song was recorded at The International Centre for the Advancement of the Arts and Sciences of Sound in
Los Angeles, California and mastered by
Howie Weinberg and Will Borza at Howie Weinberg Mastering. "Rescue Me" was officially revealed on March 22, 2018, at a press release for the announcement of the band's fifth album
America. The band premiered the song on
Vevo on March 30, 2018, one week before the album's release. An earlier version of the song is performed by Jared Leto in the documentary film
Artifact (2012). Jared Leto explained that the lyrics of the song explore themes such as pain, empowerment, faith, and freedom. He further called it a song about "the brutal war so many of us wage against fear, depression and anxiety in the hope that we might, one day, live a life filled with happiness and dreams". Will Lavin from
Joe acknowledged eclectic influences that resonated throughout the track, featuring elements from genres as varied as rock, pop and
dance music. Alex Lai from
Contactmusic commented that "beats, samples and electronics" provides the backdrop to Leto's "unmistakeable" vocals. ==Music video==