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Retapamulin

Retapamulin is a topical antibiotic developed by GlaxoSmithKline. It is the first drug in the new class of pleuromutilin antibiotics to be approved for human use. It is marketed as an ointment under the brand names Altabax and Altargo.

Indications
Retapamulin is indicated for the topical treatment of impetigo due to Staphylococcus aureus (methicillin-susceptible only) or Streptococcus pyogenes. ==Pharmacology==
Pharmacology
Mechanism of action Retapamulin is an antibacterial agent, specifically a protein synthesis inhibitor. The medication selectively inhibits bacterial protein synthesis by interacting at a site on the 50S subunit of the bacterial ribosome through an interaction that differs from other antibiotics. Pharmacokinetics Systemic exposure following topical application through intact skin is low. ==Contraindications==
Contraindications
None yet reported. ==Adverse reactions==
Adverse reactions
The most common reported adverse reaction was irritation at the application site. ==References==
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