Jamie along with his older brother serve as principals at Reuben Brothers Limited, the private family investment office founded and run by his father and uncle David and Simon Reuben. In 2011, Jamie Reuben, on behalf of Reuben Brothers Limited and alongside financier Andrew Danenza, co-founded the investment firm Melbury Capital. As of 2025, Melbury Capital is considered a micro-entity with increasing liabilities and a negative net worth. In the 2012
London mayor election, Jamie served as chairman of
Boris Johnson's re-election campaign committee. He has donated £816,000 to the
Conservative Party, and is a member of the party's
Advisory Board for significant donors. In May 2018, Jamie's father and uncle bought the
Burlington Arcade shopping mall and appointed Jamie as
managing director. On 8 October 2018, Jamie's best friend Amit Bhatia, who serves as the chairman of London-based
football club Queen's Park Rangers, appointed Jamie as a club board member. Jamie stepped down from this role in October of 2020. In March 2021, Jamie was appointed co-chair to the Growth Board of
homelessness charity
Centrepoint. In October 2021, Jamie's father and uncle became minority co-owners of Newcastle United Football Club after they acquired a 15% equity stake in the club. They appointed Jamie as a board member. == Personal life ==