Wolfram's work is focused on economics of energy industries. She has conducted numerous research projects focusing on energy and
environmental economics. She has worked on analyzing rural electrification programs in the developing world,
energy efficiency programs in the US, the effects of environmental regulation on energy markets, and on developing statistical measures for improving business and policy decisions. Wolfram's later work focuses on randomized controlled trials regarding the energy policy in both developed and developing countries.
Economics of energy industry Wolfram studied the bidding behavior regarding the daily electricity auction in U.K., and found that bidding applies to all infra-marginal units if set at a high equilibrium price. She published a paper in the late 1990s on an empirical study on Britain's electricity industry, and derived price-cost markup estimates via approaches not relying on cost data. Her study indicated that prices were lower than the range predicted by the theoretical models, and highlighted various factors for the price levels. Wolfram studied the work of Fred Kahn and discussed the technological advancements in the energy industry along with the constraints regarding proliferation of time-varying electricity pricing. In late 2010s, she published an article about the
Weatherization Assistance Program and found the upfront investment costs to be twice the actual value of the energy savings.
Rural electrification in developing countries Wolfram has conducted a number of studies regarding energy demand in the developing world. She argued that the forecasts for energy demand in the emerging economies of the world are understated and that these countries will play a major role in driving medium-run growth in energy consumption. Wolfram conducted a study on electrification for under grid households in rural Kenya. She provided evidence for low electrification rates despite the investments in grid infrastructure.
Privatization and restructuring in the US and UK Wolfram published a paper in 1999 regarding the duopoly power in the British electricity spot market and presented the results of an empirical study that indicated the prices to be higher than the marginal costs but still lower than the range predicted by most theoretical models. She also provided possible explanations for the observed price levels. In mid 2000s, Wolfram authored a paper assessing the impact of electricity industry restructuring on generating plant operating efficiency using the plant-level data. Her study indicated that the largest reductions in nonfuel operating expenses and employment were experienced by the investor-owned utility plants in restructured environments. Wolfram's study on cost minimization in regulated environments indicated modest medium-term efficiency benefits from replacing regulated monopoly with a market-based industry structure. ==Public service==