The NEO PI-R has been used in research pertaining to both (a)
genotype and personality and (b)
brain and personality. Such studies have not always been conclusive. For example, one study found some evidence for an association between NEO PI-R
facets and
polymorphism in the
tyrosine hydroxylase gene, In a study published in
Science, Lesch et al. (1996) found a relationship between the
serotonin transporter gene regulatory region (
5-HTTLPR) and the neuroticism subscale. Individuals with a shorter
allele had higher neuroticism scores than individuals with the longer allele. The effect was significant for heterozygotes and even stronger for people homozygous for the shorter allele. Although the finding is important, this specific gene contributes to only 4% of the phenotypic variation in neuroticism. The authors concluded that "if other genes were hypothesized to contribute similar gene dosage effects to anxiety, approximately 10 to 15 genes might be predicted to be involved."{{Cite journal | author =
Lesch, K. P., Bengel, D., Heils, A., Sabol, S., Greenberg, B., Petri, S., Benjamin, C., Hamer, D. & Murphy, D. | title = Association of Anxiety-Related Traits with a Polymorphism in the Serotonin Transporter Gene Regulatory Region | journal =
Science | volume = 274 | year = 1996 | pages = 1527–1530 | doi = 10.1126/science.274.5292.1527 | pmid = 8929413 | issue = 5292 ==See also==