The story centers on Dr. Rex Morgan, who in 1948 moves to the fictional small town of Glenwood to take over a late friend's practice. Helping him grapple with a dizzying array of medical problems is his old friend's office manager and nurse, June Gale. Morgan and Gale collaborated in resolving the medical and emotional problems of patients and friends over the years. Among their patients was feisty elder Melissa Clairidge, introduced in 1951. She was not used after 2012 except for a flashback story in 2020. Rex's former classmate Keith Cavell was introduced in 1957 and starred in occasional story lines until he was killed off in 1995. Young Dr. Brice Adam sometimes had a story to himself from 1970 to 1978, for example in a situation which saw him taken hostage by two felons who had
meningitis. Rex and June married in 1995. They introduced their first child, a daughter named Sarah Ann Morgan, on February 22, 2000. Dallis claimed he created the strip to inform the general public about medical issues in an entertaining manner. For instance, a continuity from 1970 depicted the plight of an attractive young woman who frequently experienced gaps of "missing time": Morgan diagnosed her as suffering from
petit mal. In later years, the story plots moved away from medical themes as Rex and June alternated in stories, confronting threats and danger from a variety of malfeasants. A popular story took place in 2006, in which longtime character Dr. Troy Gainer was revealed to be a fraud. Beginning in 2016, artist-writer
Terry Beatty often put Rex back in medical settings, either at his clinic or in the hospital. Beatty also had Morgan tackle
pseudoscience in the form of a scam perpetrated by recurring
con artist René Belluso, as discussed in a 2019 interview in
Skeptical Inquirer. In 2019, the strip introduced Marti, a friend of Sarah's with
Down syndrome. In January 2022 Belluso returned, threatening a multi-million dollar lawsuit against Sarah (who allegedly committed intellectual theft involving characters Belluso said he created) in a bid to get revenge against Rex for his part in ending Belluso's pseudoscience scam. On the 30th, attorney Barry Stuhr was introduced. ==Artists and writers==