RGS14 is a member of the
regulator of G protein signalling family. This protein contains one
RGS domain, two
Raf-like Ras-binding domains (RBDs), and one
GoLoco motif. The protein attenuates the signaling activity of
G-proteins by binding, through its GoLoco domain, to specific types of activated,
GTP-bound
G alpha subunits. Acting as a
GTPase activating protein (GAP), the protein increases the rate of conversion of the GTP to
GDP. This hydrolysis allows the G alpha subunits to bind
G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. Conversely RGS14 is enriched in
CA2 pyramidal neurons and suppresses
synaptic plasticity of these synapses and
hippocampal-based learning and memory. ==Interactions==