Rheumatoid nodulosis

The classic description of rheumatoid nodulosis in adults is that it is a variation of rheumatoid arthritis (RA) that appears as a proliferation of subcutaneous nodules, frequently on the hands and feet, linked to palindromic rheumatism without loss of joint function and with minimal to no systemic symptoms. == Mechanism ==

There are numerous theories regarding the pathophysiology of nodules linked to RA, and none of them are entirely accepted. It is believed that these immune complexes cause the release of chemotactic factors by activating nearby macrophages. More macrophages are drawn in by this process, which ultimately results in the formation of granulomas with central necrosis. == Treatment ==

Generally, there is no need for treatment for the lesions; however, on rare occasions, nonsteroidal anti-inflammatory medications or intralesional corticosteroids may be necessary. In patients with severe local discomfort who are highly symptomatic, resection may be an option. == Epidemiology ==

About 20% of people with rheumatoid arthritis develop rheumatoid nodules, which are linked to more severe erosive disease in those patients. The nodules are more common in men, typically manifest in the fifth decade of life, and are primarily found on extensor surfaces like the backs of the fingers and elbows, though they can occur anywhere. == See also ==