as El Indio Amaro,
Carolina Miranda as Vicenta Acero,
Diego Cadavid as Señor Romero, and
Gaby Espino as Indira Cárdenas.
Main characters •
Carolina Miranda as Vicenta Acero / La Coyote, she is a
coyote that is dedicated to crossing migrants on the border, half-sister of Salvador Acero and girlfriend of Daniel Phillips. After assassinating Chucho Casáres, Vicenta and her family wanted by the corrupted Mexican government because of the death of Chucho Casáres. •
Luis Ernesto Franco as Daniel Phillips, he is an immigration police officer, boyfriend of Vicenta and son of Victoria Phillips. He works with Los Aceros crossing immigrants on the border. After helping Indira to rescue her son, his charges with justice are lifted and he returns to
Department of National Security after of Indira's dimismissal by the death of Officer Sánchez. •
Ana Lucía Domínguez as Marta Mónica Villalobos / La Tuti, after having inherited all of Carlos Delgado's money, La Tuti teamed up with El Roscas to destroy El Indio Amaro due to wanting her revenge for him making her believe her son Álvaro was dead. She, Marcelo, and El Roscas create the de la Habana cartel. •
Diego Cadavid as Julián Martínez Montero, better known as Señor Romero or Julián Romero, is a Colombian drug lord and leader of the
Cali cartel, later new leader of the
Tijuana cartel who turns out is the son of Briceida Montero and Teca Martínez. While arriving in Mexico to avenge the death of his mother, his biological father, his half-brother and family, he is poses as a human rights lawyer who begins to form an obsession and vendetta over Vicenta in order to destroy the Acero-Quintanilla clan. •
Jorge Zárate as El Indio Amaro, is the main enemy of Los Aceros. With the help of Indira and the president of Mexico, he raises the Tijuana cartel again. Finally he is executed and mortally crashed with a rock by Gallo Quintanilla and the Acero brothers. •
Gaby Espino as Índira Cárdenas, she is the corrupted head of the
Department of National Security. She is Nicolás's mother and Jorge's ex-wife. She works for El Indio Amaro and fights to have custody of his son and later dismissed from her position for the murder of Officer Arturo Sánchez. Dies in the explosión.
Recurring characters •
Michel Duval as Salvador Acero, he is the half-brother of Vicenta, and Rosario's boyfriend. Together with his sister they cross migrants on the border of Mexico. •
Mauricio Henao as José Ángel Godoy / Pepote, After Salvador castrated him and was left dead. José Ángel is rescued by El Indio Amaro and Mario Casas and is forced to work for them. Finally he dies in the explosion in the cabin caused by himself. •
Alberto Agnesi as Marcelo Dóriga. After Aracely's death, Marcelo prevents Mario from keeping custody of Elizabeth. Marcelo joins forces with La Tuti and El Rosca and create the de la Habana cartel and he die together with Mario during their final confrontation. •
Rodrigo Guirao as Mario Casas, is a pharmacist and scientific engineer, who tries to destroy the life of Marcelo, father of Elizabeth and boyfriend of Andrea. In this season it is revealed that Mario suffers from obsession with Aracely, even after her death and he die together with Marcelo during their final confrontation. •
Óscar Priego as Erick Quintanilla / El Gallo, after fleeing for a long time from the police and the Mexican government, he manages to find evidence to incriminate the president of Mexico Heriberto Roca and becomes the Municipal President of
Matamoros. •
María Fernanda Quiroz as Frida Cuevas, she is a lawyer and ex girlfriend of Daniel and later arrested for incriminating evidence against Gregory without consent and also for attempting to evade justice. • Gibrán Cantú as Fiambré, he is one of Romero's security men. • Yasmary Delgado as Lázara, better known as La Glu Glu, she is a transgender woman who works for La Tuti. == Episodes ==