Napoli Insigne initially chose the shirt number 42 at
Napoli, as his older brother and Napoli teammate Lorenzo wore the number 24, but later chose the number 30, and finally the number 94, as it represented the year of his birth. After playing for the
Napoli Primavera side in the club's youth system, he made his professional debut for the club's senior side under manager
Walter Mazzarri in the
Europa League on 6 December 2012, in a 2–0 home defeat against
PSV Eindhoven; his first appearance in
Serie A came on 13 January 2013, as he appeared as a very late substitute in a 3–0 home win against
Palermo, playing alongside his older brother. In August 2014, he was sent on loan from Napoli to
Reggina. On 15 July 2015, both Insigne and his young Napoli attacking teammate
Gennaro Tutino were sent on loan to
Avellino with an option to buy. On 12 January 2017, Insigne was sent on loan from Napoli to
Serie B side
Latina, where he was assigned the
number 9 shirt. On 23 July 2017, it was announced that Insigne would be loaned to newly promoted Serie B side
Parma for the
2017–18 season.
Benevento On 21 July 2018, Insigne joined with
Serie B side
Benevento on loan until 30 June 2019. On 23 June 2019, Insigne signed permanently with Benevento. On 29 June 2020, Insigne helped Benevento secure promotion to the
Serie A with seven matches to spare. At the time, Benevento had won 23 of their 31 league games and lost just once, and had a 24-point advantage over nearest rivals
Crotone and
Cittadella. It was Insigne's first goal ever in the top division of Italian football. It was also only the second time in
Serie A history that two brothers have scored against each other in a game; Hungarian pair
István and
Ferenc Nyers did the same back in 1949, while playing for
Inter Milan and
Lazio respectively. On 12 July 2023, Insigne signed for Serie B club
Palermo on a three-year deal. After two lacklustre seasons, on 24 July 2025 Insigne left Palermo to sign for newly-promoted Serie B club
Avellino. ==International career==