Since 1998, Lana has written screenplays for such directors as Marilou Diaz-Abaya Mel Chionglo and Maryo J. de los Reyes. His screenplay for Diaz-Abaya's
Sa Pusod ng Dagat (1998) won Lana the Best Screenplay award from the Brussels European Film Festival|Brussels International Film Festival in 1998. He has won two
FAMAS Best Screenplay awards — in 1998 for
Jose Rizal (shared with Ricky Lee and Peter Ong Lim) and in 1999 for
Soltera (shared with Jerry Lopez Sineneng). His screenplay for
Jose Rizal also won awards from the
Metro Manila Film Festival and the Star Awards for Movies. In 2005, Lana's Palanca-award-winning play
Mga Estranghero at ang Gabi (1994) was adapted for film by Rody Vera. Renamed
Pusang Gala and directed by Ellen Ongkeko-Marfil, the film was nominated for several FAMAS awards, including a Best Story nomination for Lana. Lana made his film directorial debut with
Gigil (2006), starring Katrina Halili. The following year, he wrote and directed
Roxanne. From 2006 until 2014, Lana was employed by
GMA Network, where he served as a creative consultant for the drama department, and as head writer of
Magpakailanman and other shows. Lana also directs for television, sometimes in collaboration with actor Cesar Montano. For GMA Network, he directed his Palanca Award-winning teleplay
Milagroso, which was aired as a television special and became a finalist at the 2006 Asian TV Awards. Lana has also directed television episodes for
Love2Love,
Wag Kukurap, and
Fantastikids. His 2012 film
Bwakaw was selected as the Filipino entry for the
Best Foreign Language Oscar at the
85th Academy Awards, but it did not make the final shortlist. In 2014, Lana and frequent filmmaking partner, Perci Intalan, established
The IdeaFirst Company, a creative content creation and consultancy company. The company has produced many films, which have been awarded in numerous screenings in the Philippines and overseas. In the 29th
Tokyo International Film Festival, his 2016 film
Die Beautiful won the festival's Audience Choice Award, and also the Best Actor award for
Paolo Ballesteros. In 2019, he won the Best Director Award for his feature film
Kalel, 15 at the
Tallinn Black Nights Film Festival. The film had its world premiere in the Estonian capital where it was screened in the official selection. In 2023, his new feature
Your Mother’s Son was screened at the
Toronto Film Festival.{{cite web == Personal life ==