In 2000, prior to his graduation from Stanford, Botha became director of corporate development for
PayPal. He moved on to vice-president of finance and was named
chief financial officer (CFO) in September 2001. PayPal went public in February 2002, and was purchased by
eBay in October 2002.
Meg Whitman offered Botha the opportunity to stay on as CFO post-acquisition, but venture capitalist
Michael Moritz, who had invested in PayPal and served as a board member, offered him a partnership, which he accepted in January 2003. At
Sequoia Capital, Botha oversaw the firm's investment in
YouTube,
Instagram, and
Block (formerly Square), among others. He helped to plan the acquisition of
Xoom by
PayPal. In 2017, Botha assumed responsibility for Sequoia's U.S. operations from
Jim Goetz. In April 2022, Sequoia announced that, starting in July 2022, Botha would replace Doug Leone as Senior Steward of Sequoia's global brand and operations. Botha has led or co-led Sequoia's investments in several early and growth stage companies. As of 2022, his active investments include
Ethos Technologies,
Evernote, GenEdit, Landis, mmhmm, Pendulum, Skiff, Temporal Technologies, and The Org. On October 9, 2023, Botha became chairman of the board of directors at
Unity Technologies. In November 2025, Botha resigned from his role as managing partner at Sequoia. He remains an advisor to the venture capital firm and retained his board positions but was formally succeeded by
Alfred Lin and Pat Grady. Botha's tenure saw to "more than $50 billion in profit [returned to limited partners]".
The Wall Street Journal reported that Sequoia's partners challenged Botha's leadership style as well as his handling of the firm's Chinese investment business spin-off. ==Personal life==