Following his internship, Nicoll returned to the
National Institutes of Health (NIH) as a researcher. His long-term research goal has been understanding how electrical activity re-configures brain connections. His work focuses on changes in nerve circuitry that may occur over time, a phenomenon known as plasticity, which has revealed new details of
synaptic plasticity, and led contemporary knowledge of the basic mechanisms by which neurons communicate through neurotransmitters, in a process known as
synaptic transmission. Nicoll has served on the editorial board of the
Journal of Physiology. == List of awards and honors ==