The Diocese was created by Pope
John Paul II on June 28, 2003 through his
apostolic letter Quoniam Quælibet. The diocese was canonically erected on August 22, 2003, with the installation of its first bishop, Deogracias S. Iñiguez, then
Bishop of Iba, Zambales. Upon Iñiguez's resignation on January 25, 2013,
Antipolo Auxiliary Bishop Francisco M. De Leon was named Apostolic Administrator of the diocese. On October 14, 2015,
Pope Francis named
Pablo Virgilio S. David,
auxiliary bishop of
Archdiocese of San Fernando in Pampanga, as the second bishop of Kalookan and installed on January 2, 2016. On October 6, 2024, Pope Francis appointed Bishop David a cardinal effective on December 7, 2024. He is the tenth Filipino to join the
College of Cardinals, the third Filipino made a cardinal by Pope Francis, the first cardinal from Diocese of Kalookan, and the first cardinal from any diocese in the Philippines. On October 23, the
Synod of Bishops elected David a member of the Ordinary Council of the General Secretariat of the Synod. ==Statistics==