Tompkins, who had helped her mother make quilts as a child, began to quilt seriously about 1980, while making a living as a practical nurse in the Bay Area.She said she believed God directed her hand and her art. Her abstract, improvisational compositions often had a personal significance: one of her more well-known works, "Three Sixes," involves three relatives whose birthdays include the number 6. Leon featured her work on the cover of the catalog for an exhibition he organized, ''Who'd A Thought It: Improvisation in African-American Quiltmaking'', which debuted at the San Francisco Craft and Folk Art Museum in 1987 and traveled for several years. Tompkins' quilts were featured in a solo exhibition at the
Berkeley Art Museum and Pacific Film Archive (BAMPFA) in 1997, at Peter Blum Gallery in
New York City in 2003, and at the
Shelburne Museum in
Vermont in 2007. They were also included in the 2002 Biennial of the
Whitney Museum of American Art and have been shown at the
National Museum of Women in the Arts in
Washington, DC; one image is available on their web site. In 2016, her quilts were featured in an exhibition of five quilt artists at the
Oakland Museum of California. The curator of the Berkeley show,
Lawrence Rinder, wrote: In front of Tompkins's work I feel that certain
Modernist ambitions may in fact be achievable. Here are feelings of awe, elation, and sublimity; here is an absolute mastery of color, texture and composition; here is inventiveness and originality so palpable and intense that each work seems like a new and total risk, a risk so extreme that only utter faith in the power of the creative spirit could have engendered it." Critics were equal in their praise: "Tompkins'
textile art [works ... demolish the category"; "These quilts are works of such distinction and devotion that they supersede established art-historical categories, forcing reviewers to retreat to that dumbfounded admiration that attracted us to art in the first place". Throughout her career, Tompkins focused much of her work on storytelling as well as religious themes. Tompkins was deeply religious and used this as the main motivator in creating her quilts. ==Artwork==