Route 46 was a limited stop bus route, identified as a "Quickbus", operated by the Maryland Transit Administration in Baltimore. The line ran from the Cedonia Loop in Northeast Baltimore to the Paradise Loop, in Catonsville. Service operated every 15 minutes during rush hour only. The line served the corridors of Frederick Avenue in West Baltimore, and Sinclair Lane/Cedonia Ave in Northeast Baltimore including the communities of Yale Heights, and Gwynns Falls in West Baltimore, and Berea and Parkside in East Baltimore.