Main •
Mark Feuerstein as Dr. Henry "Hank" Lawson, a formerly successful New York
E.R. doctor, who is fired from his job after a wealthy hospital benefactor dies in his care. When he saves someone's life during a trip to
the Hamptons, he accepts an offer from Boris, a
German businessman, to remain as a "
concierge doctor" in his palatial estate. He usually attends to wealthy clientele, but also others in need of care and often without the means to pay. According to the episode "Keeping the Faith", he and his brother are
Jewish. •
Paulo Costanzo as Evan Roth Lawson, Hank's younger brother. He is an accountant and self-appointed
CFO of HankMed. Evan's job is to promote the HankMed business, at times using strategies that Hank finds inappropriate or too commercial. At the end of season 4, he marries Paige, the adopted daughter of a wealthy, conservative military man who is running for the
United States Congress. When Boris buys Hampton Heritage hospital in Season 7, he becomes a member of the board and the hospital's Acting Administrator. •
Reshma Shetty as Divya Katdare, Hank's
physician assistant. She proposes the idea of a concierge practice and is invaluable to Hank. She initially has to keep her medical career a secret from her parents. Forced by her parents into an arranged betrothal to a childhood friend, she has broken free of their control and is living on her own. As of season 6, Divya has a daughter named Sashi, but is involved in a bitter custody dispute with Sashi's father Rafa. •
Jill Flint as Jill Casey (seasons 1–4; recurring, season 8), Hank's on again/off again girlfriend and an administrator at Hamptons Heritage. Jill works with Hank to open a free clinic while also running the local community hospital. In the fourth season, she leaves the Hamptons to do relief work in
Africa. •
Brooke D'Orsay as Paige Lawson (seasons 4–8; recurring, seasons 2 & 3), Evan's wife. Paige is the daughter of a wealthy, conservative former military officer with political aspirations who initially does not think Evan is good enough for his daughter. Paige and Evan meet when she hires him to play her pretend boyfriend, but their pretend relationship soon blossoms into a real one. She pursues a career in Art and soon becomes a curator for art collectors in the Hamptons. In the season 4 episode "Who's Your Daddy?", she is revealed to be adopted, and in the season 4 two-part finale/special "Off-Season Greetings", she and Evan marry. •
Ben Shenkman as Dr. Jeremiah Sacani (seasons 5–8; recurring, season 4), was hired by Evan to be Hank's replacement during Evan and Hank's temporary halt to their business partnership; Sacani stayed on when Hank and Evan made peace. He is an accomplished researcher and excels at his work, although he has limited social skills and an awkward bedside manner. Sacani is an heir to a vast fortune. He and Divya become best friends. She moves into his house in Season 6 when she is facing financial troubles and is pregnant with Sashi. Their friendship is almost broken when Divya meddles in and almost destroys Sacani's relationship with a woman named Viviana. In season 7, Sacani is conned out of a great deal of money from a former fellow college classmate. •
Campbell Scott as Boris Kuester von Jurgens-Ratenicz (seasons 4 & 5; recurring, seasons 1–3 & 6–8), a wealthy and titled German businessman who offers Hank and Evan his guest house, and is Hank's first client. Boris has a genetic disease he is determined will die with him, and which he fights with equal determination. He often seeks rare or risky treatments. Used to getting what he wants, Boris has a rigid code of conduct, which at times puts him at odds with Hank. In season 3 he has a son, Carlos, with his wife Marissa. In Season 6, he buys Hampton Heritage hospital, stating that he intends to settle permanently in the Hamptons. He persuades Hank, Evan, Divya and Jeremiah to become members of the hospital's Board of Directors but has a secret agenda.
Recurring •
Henry Winkler as Eddie R. Lawson, Hank and Evan's loving, ne'er-do-well father who left the boys when they were young. Accused of embezzlement, Eddie served a short term in prison and is now on parole, a best-selling author and has been rebuilding his relationship with his sons and his new-found daughter Emma. •
Anastasia Griffith as Dr. Emily Peck, an arrogant rival doctor who works with (and becomes briefly involved with) Hank. Emily is hired to substitute for Hank while he makes an extended visit to
Cuba with Boris, and soon comes into conflict with Divya because of her arrogance and her detached approach to her patients. •
Michael B. Silver as Ken "Killer" Keller, a sports agent and Hank's former high school bully. While Hank is initially hostile to him they develop a mutual respect and friendship. By season 5 Keller joined HankMed as the practice's lawyer. •
Tom Cavanagh as Jack O'Malley, a pro golfer who was featured in the season-two episode "Mulligan" and later became a recurring character in season 3, as his friendship with Hank became more pronounced. Jack died in the season 3 episode "Hank and the Deep Blue Sea" which caused Hank to develop emotional trauma. •
Kyle Howard as Dr. Paul Van Dyke (nicknamed "P.V.D."), a staff doctor at Hampton's Heritage; Divya first meets him while moonlighting at the hospital. After a brief flirtation between Divya and him, Evan hires him as one of Hank's replacements during the temporary halt to the business partnership between Hank and Evan. Van Dyke's personality is very energetic and impulsive, which has gotten him into awkward situations professionally and socially. Van Dyke would later join the new HankMed. He had a pet rabbit of which he was very fond. He also has a slightly older
fraternal twin brother named Daniel (nicknamed "D.V.D."). •
Anna George as Rubina Katdare, Divya's reserved and loyal mother. She follows the traditions of a traditional
Indian housewife, a sympathetic ear to Divya's frustrations and a bridge to Divya's father. When Divya's father disowns her, Rubina secretly keeps a relationship with Divya. She is eventually inspired by Divya to follow her heart, which causes her to leave her husband and travel the world. •
Ajay Mehta as Devesh Katdare, Divya's strict and strait-laced father. He disowns Divya when she cancels her wedding with Raj (
Rupak Ginn), but they reconcile once she becomes his nurse after he nearly drowns. •
Willa Fitzgerald as Emma Lawson, the half sister of Evan and Hank Lawson. She travelled to the Hamptons to find her biological father. •
Ryan McCartan as Cinco Phillips; he’s treated by Hank and later comes into conflict with Emma. ==Episodes==