The Great War Details of the 95th Saskatchewan Rifles were placed on active service on 6 August 1914 for local protective duty. Lieutenant-Colonel A. C. Garner commanded the battalion throughout its existence.
Between the Wars On 15 May 1924, following extensive reorganizations of the Canadian Militia, each of the South Saskatchewan Regiment's battalions became a distinct regiment, and the Regina Rifle Regiment was created from the 1st Battalion. In the 1936 reorganization of the Militia, the Headquarters and A Company of the 12th Machine Gun Battalion,
CMGC, merged into the Regina Rifles, which existed as a single battalion militia regiment until 1939. The regiment mobilized the 3rd Battalion, The Regina Rifle Regiment, CASF, for active service on 12 May 1942. It was subsequently redesignated the 2nd Airfield Defence Battalion (The Regina Rifle Regiment), CASF, on 19 July 1943 and served in Canada in a home defence role as part of Pacific Command. It was disbanded on 15 November 1943.
2015 onwards Soldiers of the Royal Regina Rifles contribute to domestic and expeditionary operations on a regular basis. ; Operation Lentus : Wildfires in Saskatchewan's north threatening life and property of Canadians. ;
Operation Reassurance : NATO's commitment to stability in Eastern Europe.
Freedom of the city On 5 September 2015, the largest freedom of the city parade in Regina since the end of the Second World War was exercised by the Royal Regina Rifles. Collaborating with all local military units (; 10th Field Artillery Regiment, RCA; 38 Signal Regiment; 38 Service Battalion; 16 Field Ambulance; and
15 Wing Moose Jaw) a Canadian Armed Forces Open House was held at the Regina Armoury throughout the day. The culmination of the day was a charity gala dinner entertaining over 315 guests. The patron for the evening was the Lieutenant Governor of Saskatchewan. The charity raised seed money for a rewrite of the regimental history. Previous to that a freedom of the city was exercised by the Royal Regina Rifles in Regina on June 4, 2007. ==Perpetuations==