•
Albert J. Ruffo (1908–2003), American politician •
Andrée Ruffo, Canadian judge •
Antonio Ruffo (1610s–1678), Sicilian politician, nobleman, patron, and collector •
Armand Garnet Ruffo (born 1955), Canadian scholar, filmmaker, writer and poet •
Bruno Ruffo (1920–2007), Italian motorcycle road racer •
Dennis Ruffo, Canadian music promoter •
Ernesto Ruffo Appel (born 1952), American-born governor of Baja California •
John Ruffo (born 1954), American business executive •
Johnny Ruffo (1988–2023), Australian singer, songwriter, dancer, actor and television presenter •
Leonora Ruffo (1935–2007), Italian film actress •
Marco Ruffo, Italian architect •
Pietro Ruffo (born 1978), Italian artist •
Titta Ruffo (1877–1953), Italian baritone •
Victoria Ruffo (born 1962), Mexican actress •
Vincenzo Ruffo (c. 1508–1587), Italian composer of the Renaissance ==See also==