As stated above, the Russell–Brasstown Scenic Byway is composed of parts or entire lengths of numbered routes. The portion of SR 75 included in the byway was established between May and August 1932 along the same alignment as it travels today. By July 1939, this section of SR 75 was converted from "completed grading, not surfaced" to "completed semi-hard surface". By 1941, a short section northwest of the SR 75 Alternate was paved. By July of that year, the former southern segment of
SR 66 was established from the current SR 17/SR 75/SR 180 intersection to the current SR 180/SR 180 Spur intersection. Also, SR 180 was established from the latter intersection westward to an intersection with
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SR 11 west of Choestoe. By the end of 1946, the above-mentioned segment of SR 75 was paved. Between 1950 and 1952, SR 17 was designated along SR 75. Between 1960 and 1963, SR 66 from SR 17/SR 75 to SR 180 was paved. By 1966, the byway's entire segment of SR 180 was paved. Also, SR 348 was established in two parts. The southern part began at an intersection with
SR 356 (what is now SR 75 Alternate) to the White–Union county line. The northern part existed south and southeast of Choestoe, intersecting with SR 348 in Choestoe. Later that year, both parts of SR 348 were connected, and the entire byway was paved. By 1982, SR 356 was redesignated as SR 75 Alternate. Later that year, upon the
decommissioning of SR 66, that segment of the bypass was redesignated as an eastward extension of SR 180. The Russell–Brasstown Scenic Byway was designated as a National Forest Scenic Byway on June 5, 1989. It was later named a Georgia State Scenic Byway in 1992 and a National Scenic Byway on June 15, 2000. ==Major intersections==