By the early 1590s, Lopes was wealthy and generally respected. He owned a comfortable house in Holborn and had his youngest son Anthony enrolled at
Winchester College. He incurred the fury of one of his former patients, Queen Elizabeth's
favourite Robert Devereux, Earl of Essex, when he described to Dom António and the Spanish statesman
Antonio Pérez occasions on which he had treated Essex for
venereal diseases. Learning of this from Pérez, Essex began to assemble evidence implicating Lopes as some sort of
fifth columnist in the pay of
King Philip II of Spain. The
Lord High Treasurer Lord Burghley initially thought Essex's allegations against Lopes absurd. The Queen herself also rebuked Essex. , a major figure in Lopes's downfall Late in 1593, Essex discovered a secret correspondence between Estevão Ferreira da Gama, one of Dom António's former supporters, and officials in the
Spanish Netherlands—and had a messenger, Manuel Luis Tinoco, arrested. Lopes's courier Gomez d'Avila, a London-based Portuguese New Christian, was also arrested. Both implicated Lopes during interrogation. On 28 January 1594 Essex wrote to
Anthony Bacon of "a most dangerous and desperate treason", the target of which was Queen Elizabeth: "The executioner should have been Dr Lopus. The manner by poison." Parallels were drawn with a letter written by Andrada to Burghley in 1591, in which reference was made to a plot whereby the King of Spain would deploy "three Portuguese to kill her Majesty and three more to kill the King of France". Tinoco was tortured and Ferreira da Gama threatened with torture until they confessed along the lines Essex suspected; Ferreira da Gama, asked if Lopes might have been willing to poison the Queen, replied in the affirmative. Lopes was arrested and held first at Essex House, then the
Tower of London. He confessed when threatened with torture, but promptly recanted this statement. Revelations regarding Lopes's secret correspondence with Spanish officials did not help his case, particularly when it emerged that he had given the Spanish information about the English court and apparently donated money to a secret
synagogue in Antwerp. Burghley and the spymaster
William Wade were soon "ready to believe the worst", to quote Samuel. Lopes, Ferreira da Gama and Tinoco were tried by a commission headed by Essex at
Guildhall on 28 February 1594. Lopes insisted that he was innocent. The prosecutor,
Sir Thomas Egerton, denounced the doctor as "a perjured, murdering villain and a Jewish doctor worse than
Judas himself". The three were convicted of
high treason and sentenced to death. The Queen waited over three months before signing the
death warrant; this delay is sometimes interpreted as evidence that the Queen doubted the case against her doctor. Lopes, Ferreira da Gama and Tinoco were
hanged, drawn and quartered at
Tyburn on 7 June 1594. Lopes insisted to the end that he was innocent and that his professed Christian faith was genuine. He fell into a state of depression, but on the scaffold gathered his resolve and, according to the 16th-century historian
William Camden, declared that "he loved the Queen as well as he loved
Jesus Christ". The crowd roared with derision and laughter, taking this, from a man of Jewish background, for a thinly veiled confession. Lopes's property was forfeited on his
attainder. His widow Sarah petitioned the Queen to be allowed to keep his estate; the Queen kept the ring given to Lopes's daughter by the Spanish, but returned the rest. Elizabeth also granted £30 per year to Anthony to support him at Winchester. A letter written by the Spanish diplomat
Count Gondomar to
King Philip III of Spain a decade after the trial seems to indicate that Lopes and Ferreira da Gama had been unjustly convicted, and that there had been no plot involving the Portuguese doctor: "the King our master [Philip II] had never conceived nor approved such measures ... the Count of Fuentes neither received nor gave such an order, moreover it is understood that Dr Lopez never passed through his thoughts, because he was a friend of the Queen and a bad Christian." Lopes remains the only royal physician executed in English history. ==Possible literary legacy==