Modelling and hosting Agoncillo started as a model at the age of 15, beginning as one of the early
Penshoppe's Club Pen models. He has appeared in various television commercials for a variety of products such as
Greenwich Pizza (together with
Donita Rose),
Sprite,
Smart Communications, Emperador Brandy,
Rexona, Swish mouthwash, and
McDonald's. Agoncillo became one of the original hosts of
Mornings @ GMA, an early morning variety program of
GMA Network. He also hosted
Campus Video, a short-lived program shown every Saturday morning at GMA Network. He then moved to
ABS-CBN and became a co-host on
Talk TV, which is a morning talk show co-hosted by broadcasters
Julius Babao and
Christine Bersola-Babao, and actress
Janette McBride. He also hosted
Breakfast, an early morning variety program;
Star in a Million, with
Edu Manzano and
Zsa Zsa Padilla, and
Y Speak, a youth-oriented talk show and debate forum. Both shows aired in
Studio 23, an
ABS-CBN Corporation subsidiary. He won his first KBP Golden Dove Awards for Best Talk Show Host in 2005 for Studio 23's
Y Speak. Agoncillo was the main host of
Philippine Idol alongside fellow ABS-CBN actress
Heart Evangelista on
ABC-5 (now TV5) before it was moved to
GMA Network and rebooted into
Pinoy Idol. In August 2008, he began hosting TV5's
Talentadong Pinoy, which showcases Filipino undiscovered talents. He also hosted
Endemol's
Pinoy Fear Factor which aired on
ABS-CBN.
Pinoy Fear Factor was shot entirely in
Argentina. On October 24, 2009, Agoncillo finally returned to GMA Network and began hosting the country's longest running noontime show,
Eat Bulaga!. From April 2010 to February 2011, Agoncillo co-hosted the noontime musical variety show
P.O.5 on TV5. For his hosting stints in
Eat Bulaga! and
Talentadong Pinoy, Agoncillo became a four-time award winner of the
Aliw Award for Best Male Emcee, for which he won consecutively from 2007 to 2010. In 2010, he was elevated to the Hall of Fame. Agoncillo hosted a game show called
Picture! Picture! which premiered on November 23, 2013, on
GMA Network, the show aired for 28 weeks ending on June 15, 2014. In 2015, Agoncillo was announced as the host of
Cash Cab Philippines, the Philippine edition of the game show format
Cash Cab. The show would go on to air 13 episodes on
AXN Asia from December 22. From 2020 to 2021, he was the director of the documentary show
Paano Kita Mapasasalamatan? hosted by his wife
Judy Ann Santos, marking his partial return to ABS-CBN despite his commitments to other networks.
Acting Agoncillo joined the talent cast of
ABS-CBN. He is most memorable for playing the love interest of Judy Ann Santos in the television soap opera
Krystala. He once again appeared with Santos in the movies
Kasal, Kasali, Kasalo (2006) and
Sakal, Sakali, Saklolo (2007). He received best actor nominations from different award-giving bodies for his portrayal of a confused newly-wed husband in this film. He also played a role of a husband who lost his job and became a house husband in a movie with
Judy Ann Santos titled
My House Husband: Ikaw Na! in 2011. He also played a main cast role in
Bituing Walang Ningning, an ABS-CBN soap opera featuring singer-actresses
Sarah Geronimo,
Angelika dela Cruz, and
Zsa Zsa Padilla in the leads. Agoncillo also played leading roles in
independent film projects and television drama shows. He played the distinct roles of a grease-filled beggar and a transvestite in two separate dramatic episodes of
Maalaala Mo Kaya, the biographical drama series of
ABS-CBN. He starred in the ABS-CBN television series,
Ysabella with his long-time on-screen partner and then girlfriend, Judy Ann Santos. Agoncillo returned to acting on TV with drama series titled
Pieta airing weekday afternoons over
ABS-CBN where he portrayed Rigor, a character originally portrayed by Ace Vergel. Agoncillo played the role of a high school teacher in the comedy sitcom
George and Cecil (2009) alongside his wife Judy Ann Santos who played the role of a policewoman. Agoncillo returned to acting again for his new role in
May Bukas Pa where he played a media cameraman in the final 11 episodes of the series (253–263, aired January 22–February 5, 2010) after his wife Judy Ann Santos also guested in the show (episodes 237–241, aired December 31, 2009 – January 6, 2010). Agoncillo appeared in
Lady Dada on TV5 in 2010. Agoncillo returned to acting again this time on
GMA Network with ''
My Husband's Lover as his very first television series on the network appearing in a minor role (also in a last week of the drama series), with his co-stars Carla Abellana and Dennis Trillo in 2013, and in Ismol Family'' from 2014 to 2016, also with Carla Abellana.
Photography Agoncillo had a one-man colored photo exhibit at
Glorietta, sponsored by
Fujifilm in 2007. He published a black-and-white photography coffee table book titled
Ploning – The Making as a birthday gift to his fiancée (now wife)
Judy Ann Santos in 2008. ==Personal life==