Klesko hit a home run in three consecutive World Series games against the
Cleveland Indians in Games 3, 4, and 5 of the
1995 World Series. In Game 3, he hit a solo shot off of
Charles Nagy in the seventh inning of a 7–6 loss. The Game 4 home run, another solo shot (this time off
Ken Hill) put the Braves up 1–0 in the sixth; they would win the game 5–2. In Game 5, his ninth-inning two-run home run to right field off
José Mesa was almost caught by his mother; Klesko wound up trading the man who caught it an autographed
Greg Maddux baseball for it. The Braves lost that game 5–4, but they beat the Indians for the fourth time in the sixth game to become World Series champions. Klesko hit at least 21
home runs in eight of his 13 seasons in the major leagues, with a high of 34 homers in . His most productive season came in , when he hit .286 with 30 home runs and posted career highs in
RBI (113),
runs (105),
stolen bases (23) and
slugging percentage (.539), and made the
National League All-Star team. In , Klesko hit .300 with 29 home runs and 95 RBI, and collected career-highs in
hits (162) and
doubles (39). Defensively he shuttled around the outfield and first base. In his career, Klesko compiled a .370
on-base percentage with a .500 slugging average, for an .870
OPS. His .525 slugging percentage as a Brave ranks fourth all-time among the team's career leaders, ahead of
Eddie Mathews. His .886 OPS as a Brave ranks him fifth among Braves' all-time leaders. Klesko missed nearly the entire season due to major shoulder surgery. He returned on September 21, drawing a walk as a pinch-hitter in his first plate appearance. On December 19, 2006, Klesko signed a one-year contract with the San Francisco Giants. Klesko announced his retirement from baseball on April 18, . ==Off the field==