Blackburn Rovers Having previously played football for his school whilst living in Namibia, he joined a local team shortly after moving to England before joining the Blackburn Rovers academy in 2011 aged 13. Just over a month later, on 11 August, Nyambe made his professional debut, being named in Blackburn's starting-eleven for their first round
EFL Cup fixture against
League One side
Shrewsbury Town. Nyambe assisted
Nathan Delfouneso's 30th-minute equaliser, although Blackburn went on to lose the game 2–1, and were ultimately knocked out of the cup. On 19 November 2016, Nyambe made his league debut for Blackburn, coming on as a 77th-minute substitution for
Danny Graham in a 3–2
Championship victory over
Brentford. His first league start came two weeks later, on 3 December, in a 1–1 draw with
Huddersfield Town. Despite the
2016–17 season being one to forget, as Blackburn were relegated to
League One, Nyambe came away from the season with 31 competitive appearances and the club's
Young Player of the Year award. On 21 July 2017, it was announced that Nyambe had agreed a new three-year deal with the club, with the optional for a further 12-months. After a disastrous season the season before, Nyambe helped Blackburn achieve promotion back to the Championship after finishing runners-up to
Wigan Athletic in League One at the end of the
2017–18 season. Nyambe made 35 appearances in all competitions for the club, despite suffering a hamstring injury in March 2018. Reflecting on Blackburn's promotion, Nyambe stated: "I'm very proud and it was great to enjoy the occasion with the fans." On 23 April 2019, Blackburn announced that Nyambe had signed a new two-year contract with the club, with the option for an additional year that would see the player's stay at Blackburn be extended until the summer of 2022.
Wigan Athletic Following the expiry of his contract with Blackburn, Nyambe joined
Wigan Athletic on a one-year deal.
Derby County On 19 September 2023, following his release from Wigan Athletic, Nyambe joined
Derby County on a deal until January 2024, with the option to extend. Nyambe made his debut for Derby in a 2–0 win at
Carlisle United on 23 September 2023. In his first month at the club, Nyambe became a regular starter at the right-back role for Derby and earned praise for his performances, Nyambe himself expected to improve further as he regained fitness which he lost as a free agent. On 25 December 2023, after making 11 league appearances, Nyambe signed a contract extension with Derby until June 2025. Nyambe would miss several games for Derby in January 2024, during his call up to the
2023 Africa Cup of Nations for Namibia. On 27 February 2024, Nyambe would pick up a
quadriceps injury in a match against
Charlton Athletic, in March it was confirmed that he had surgery on this injury and would be ruled out for remainder of the
2023–24 season, Nyambe made 21 appearances for Derby during the season. After playing in eleven of Derby's first twelve matches of the
2024–25 season, Nyambe would pick up a
posterior cruciate ligament injury in Derby's match against
Millwall on 19 October 2024 which would leave him on the sidelines for up to six months, Derby head coach
Paul Warne said Nyambe was "heartbroken" by the injury. He returned from injury ahead of schedule in January 2025. On 2 April 2025. Nyambe broke the record for the most Championship appearances by an outfield player without ever scoring a goal during Derby's match against Preston North End on 2 April 2025 at 202 appearances. In the game, Nyambe would sustain a hamstring injury in the fourth minute of the match and was forced to leave the field, the injury ended Nyambe's season a month early with the defender making 19 appearances during his second season at Derby. ==International career==