Supercross 2010 While leading the Main of Round 14 at St. Louis, Villopoto came up short on a triple jump and leaped from his bike, landing hard. His bike dove into the face of the third jump and flipped over several times. Medical workers arrived on the scene and cut the racing boot off his foot. Villopoto had to be carried off the track. Further examination revealed a broken right tibia and fibula and surgery was performed to stabilize it. He withdrew from the 2010 series after his Round 14 injury with 266 championship points, leaving him in 4th place by the season's end.
2011 Villopoto won his first Monster Energy AMA Supercross Championship, edging out Chad Reed by four points in the 17-race championship. Villopoto won a series-high six races throughout the season. Later, Villopoto won the inaugural
Monster Energy Cup, claiming wins in the three heats to grab a US$1 million purse. Villopoto finished 2011 leading Ryan Dungey by 12 points to claim the Lucas Oil Pro Motocross Championship.
2012 Villopoto won his second AMA Supercross Championship, capturing the title with four rounds remaining in the season. He won 9 of 16 rounds of racing.
2013 Villopoto won the 2013 Monster Energy AMA Supercross Championship. It was Villopoto's third straight AMA Supercross Series championship, putting him in an elite class of off-road motorcycle champions – only Bob Hannah, Jeremy McGrath, and Ricky Carmichael have won three straight SX titles (Hannah ’77 – ’79, McGrath ”93 – ’96, ’98 – 2000, Carmichael ’01 – ’03). Villopoto would also go on to win the Lucas Oil Pro Motocross Championship.
2014 Villipoto wrapped up his 4th straight Monster Energy Supercross championship with one round remaining in the 2014 series. On March 8, 2014, Villopoto won the 450cc Final at Daytona International Speedway. It was his 4th career win at Daytona, moving him within one win of
Ricky Carmichael's all-time record of five Daytona wins. He had previously won races in Phoenix and Oakland during the Supercross season. On April 5, 2014, Villopoto won the 450cc Main Event at Houston's Reliant Stadium, bringing his total career Supercross All-Time Wins number to 38, making him 5th place overall behind
Chad Reed. On April 26, 2014, Villopoto dominated the highly competitive Supercross race at round 16 in New York, Metlife stadium, collecting his 6th win of the season (40th of career).
2015 Villopoto chose to compete in the FIM Motocross World Championship placing first at the second race of the series in Thailand, but withdrew from the series after discovering that the injuries sustained from a crash in the Trentino GP were worse than initially realized.{{Cite web|url=http://motocross.transworld.net/videos/ryan-villopoto-crash-at-mxgp-of-trentino/#uDZpYxyejc4vQ553.97|title=Ryan Villopoto Crash At MXGP Of Trentino ==Motocross des Nations participation==