Russillo hosted
NBA Sunday,
The Baseball Show, and
ESPN Radio College GameDay during the 2008 season on ESPN Radio. He was also a regular host for
GameNight and a fill-in host for
The Doug Gottlieb Show and
All Night with Jason Smith.
Sports Illustrated's Richard Deitsch named him Best Radio Voice of 2007 for his work on ESPN Radio. He praised Russillo's "reasoned approach and knowledge across sports." He appeared regularly on several shows on
Comcast Sportsnet New England, including
New England Sports Tonight with Gary Tanguay and
Greg Dickerson, and was also a studio analyst for the
Boston Celtics' television coverage. During the NBA season, Russillo was the host of ESPN's
The NBA Today podcast, the network's #2 most downloaded podcast series. Contrary to popular belief, in December 2012, this show was not cancelled to be swapped out with
NBA Lockdown featuring former NBA player
Bruce Bowen. In September 2015, Russillo welcomed former
NFL player
Danny Kanell as the new co-host for his
Russillo Show, after
Scott Van Pelt's departure from ESPN Radio. Kanell was laid off from ESPN in April 2017, leaving Russillo as the sole host again, with multiple guest co-hosts occasionally joining him on the show. On December 20, 2017, Russillo announced he was leaving his ESPN radio show to pursue other opportunities, with his final radio show taking place on December 22. After departing his show, he continued to produce a podcast with ESPN and also made appearances across several ESPN platforms including on television with
Get Up!. In late August 2018 he re-signed with ESPN. In June 2019 Russillo re-united with old colleague Scott Van Pelt on the "SVP & Russillo" podcast. On August 5, 2019, Russillo announced on his
Twitter account that he would be leaving
ESPN at the end of August and would be joining
The Ringer as a full-time media personality. At The Ringer, Russillo hosted
The Ryen Russillo Podcast. Segments included NFL and NBA coverage, check ins with the MLB, and a Life Advice segment with Steve Ceruti and Kyle Crichton Russillo began a new venture with Barstool Sports in October of 2025, continuing his popular podcast. Beginning on January 12, 2026, the video version of his Barstool podcast began airing exclusively on
Netflix. ==Personal life==