;Lead cast •
Judy Ann Santos as Patricia Montecillo-Villamines •
Piolo Pascual as Jordan Villamines ;Main cast •
Coney Reyes as Mayla Lizandro-Montecillo - Patricia (biological), Sheila (adoptive) & Adrian's mother, but she's supposed to be a stepmother of Patricia in first scene. •
Edu Manzano as Armand Montecillo † - Chandro, Patricia & Adrian's father and Sheila's adoptive father •
Zsa Zsa Padilla as Nieves Quevedo-Pacheco † - Patricia (adoptive), Abby & Chandro's mother. •
Julia Clarete as Sheila Montecillo-Samonte - Star's biological daughter •
John Lloyd Cruz as Adrian Montecillo † - younger son of Mayla & Armand, also a younger brother of Patricia (biological) & Sheila (adoptive) and Chandro's younger half-brother. •
Armida Siguion-Reyna † as Lourdes Lizandro † - Mayla's mother and Adrian, Patricia (biological) and Sheila (adoptive)'s grandmother •
Cherie Gil † as Star † - Sheila's biological mother. •
Mark Gil † as Mr. De Guzman † - Abby's father. •
Rosemarie Gil as Emilia Villamines - Jordan and Dante's mother and also Patricia's mother-in-law. ;Also as main cast •
Angelica Panganiban as Abby De Guzman - Nieves's younger daughter from Mr. De Guzman. •
Cherry Pie Picache as Becky Pagsisisihan - Patricia's godmother. •
Carlo Aquino as Eman Dela Cruz - son of Arsing from his first wife. •
Romnick Sarmenta as Chandro † - Dra. Enriquez's adoptive son, but also he's a biological son of Armand & Nieves and Patricia's long-lost half-brother. •
Timmy Cruz as Dra. Enriquez - Chandro (adoptive) and Adelaine's mother. •
Isabel Granada † as Adelaine Enriquez † - Dra. Enriquez's daughter and also she's a long-lost biological daughter of Franco. ;Supporting cast • Priscilla Almeda as Joey † • Steven Alonzo as Adrian's friend • Jackie Castillejos as Cleo † •
Menggie Cobarrubias † as Ramil † • Alma Concepcion as Benilda Villamines • Mymy Davao as Elaine • Hazel Espiñosa as Gemma Rose - Arsing's second wife. •
Daniel Fernando as Turing † - He's knows the truth about Patricia, Chandro and Shelia's true identities. • Vivian Foz as Evelyn • Glenda Garcia as Lani's mother • Gino Paul Guzman as Red Bernardo •
Kathleen Hermosa as Babette •
Simon Ibarra as Dr. Neil Guanzon •
Cherry Lou as Julie • Manjo del Mundo as Prison Warden • Aiza Marquez as Lani • Aya Medel as Dante's mistress •
Pen Medina as Abner Pacheco - Nieves' drunk husband. •
Melissa Mendez as Nelia Domingo - Carlo's aunt and also Patricia's godmother. • Matthew Mendoza as Dante Villamines - Jordan's elder brother and also Patricia's brother-in-law. • L.A. Mumar as Carlo Samonte • Belinda Panelo as Isabel Borromeo •
Lito Pimentel as Arsing Dela Cruz - Eman's father. •
Efren Reyes Jr. as Mr. Tordesillas •
RJ Rosales † as Dexter Tolentino † •
Caridad Sanchez as Lolita Quevedo - Nieves's mother and Patricia (adoptive) Abby & Chandro (biological)'s grandmother. • Jeffrey Santos as Virgo de Padua † • Michael Conan as Fadz † • Leni Santos as Elena •
Monsour del Rosario as Mario † - Jordan and Patricia's Friend as Long Life. ;Recurring, extended and guest casts •
Yul Servo as Epoy •
Jennifer Sevilla as Dr. Escoto • Maricar Fernandez as Wendy - a
prostitute contact by Chandro to have sex photo in a Hotel Room with Jordan. •
Joel Torre as Franco Dequiros Montecillo † - Adelaine's biological father. •
Vic Vargas † as Mr. Villamines † • Ann Villegas as Shiela's Cellmate † •
Dick Ysrael † as Tats † - Shiela's biological father. ==Production==